Other than the fact that in 2WD the back end can get squirrelly easy, and 4WD improves the handling. A couple of years ago I had to drive home from the Adirondaks in the middle of a blizzard, and when I got to NJ I learned they had declared a state of emergency and private vehicles were not supposed to be on the road. 40 to 45 mph on the NY thruway was safe and manageable in 4WD, but with the light back end I would never have gone that fast in 2WD. Your mileage may vary.

k_enn