Speakers are always the weakest link. Get some really good ones... You can drive a good speaker on anything, pretty much, as long as you don't play it loud enough to go into distortion.

I might suggest something else - make the truck a better speaker box by sealing things up better in the doors and rear (leave the rear pass quarterpanel vent intact however). You should get a lot better midbass out of the front door speakers once things are sealed better...

-=RB