When towing my old pop-up and 33" Boggers on the truck I got about 12 mpg (about 2 mpg less than without the camper). Towing a 5x10 u-haul (2 axles) with about 1000 lbs of gear and 33" swampers I got about 13 mpg. With my 4,300 lb camper, my wife and two kids I averaged about 9 mpg with 31" MTs. This was pretty flat ground, from south eastern GA to Houston, TX. Best tank was about 10.5 mpg, worst was about 7 mpg (I was trying to get home and was doing about 70 mph, from my usual 60 mph). Without the camper and 31s (and the family), I get about 17.8 mpg with the AC on at 75 mph.
-Michael